Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB DNA-dependent RNA polymerase beta subunit	H420Y	-	-	Mycobacterium ulcerans	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H432Y	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H435Y	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H437R	-	-	Streptomyces coelicolor, Streptomyces griseus, Streptomyces antibioticus, Streptomyces parvulus, Streptomyces lavendulae, Amycolatopsis orientalis, Streptomyces erythraea	streptomycin\|actinorhodin\|erythromycin\|formycin\|vancomycin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H437Y	-	-	Streptomyces coelicolor, Streptomyces griseus, Streptomyces antibioticus, Streptomyces parvulus, Streptomyces lavendulae, Amycolatopsis orientalis, Streptomyces erythraea	rifampicinstreptomycin\|actinorhodin\|erythromycin\|formycin\|vancomycin	Reslit	Candidate
rpoB DNA-directed RNA polymerase subunit beta	H442R	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H442Y	C1324T	-	-	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H445A	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H445C	CAC > TGC	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	rifampicin	Card DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445D	C1333G CTG->GAT C1335G	replaces a neutral histidine with a negatively charged residue, weakening hydrogen bonding and destabilizing drug interactions, multiple resistance variants, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	rifampicinrifampicin\|rifabutin	Card DatabaseResFinder DatabaseReslit	Confirmed