Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	H445E	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase subunit beta	H445F	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase subunit beta	H445G	-	single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445L	C1333T	single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445N	C1335T C1333A	single resistance variant	Mycobacterium tuberculosis, Staphylococcus aureus	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445P	-	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445Q	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445R	CAT->CGT CAC->CGT C1333A CTG->AGG	single resistance variant	Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium bovis	rifampicincapreomycinrifampicin\|rifabutin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase subunit beta	H445S	-	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	rifampicin	Card DatabaseReslit	Confirmed
rpoB DNA-directed RNA polymerase beta subunit	H445T	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseReslit	Confirmed