Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	H502L	-	single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Clostridium ljungdahlii, Clostridioides difficile	rifampicinrifaximin	Card DatabaseReference Gene Catalog	Confirmed
rpoB β subunit of RNA polymerase	H502N	C1505T C1505A	single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Clostridium difficile, Mycobacterium tuberculosis, Clostridioides difficile, Clostridium ljungdahlii	rifampicin\|rifaximinrifampicinrifamycins	Card DatabaseReference Gene CatalogReslit	Confirmed
rpoB β subunit of RNA polymerase	H502R	-	DNA-directed RNA polymerase subunit beta RpoB	Clostridium difficile, Clostridioides difficile	rifampicin\|rifaximinrifaximin	Reference Gene CatalogReslit	Confirmed
rpoB β subunit of RNA polymerase	H502Y	-	multiple resistance variants, single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Clostridium difficile, Clostridioides difficile, Clostridium ljungdahlii	rifampicin\|rifaximinrifampicinrifaximin	Card DatabaseReference Gene CatalogReslit	Confirmed
rpoB RNA polymerase beta subunit	H511Y	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB beta-subunit of RNA polymerase	H513L	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H513R	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H516L	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H516V	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H516Y	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported