Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase B subunit	I569V	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	I572F	ATC-TTC	confer resistance to rifampicin and a fitness advantage in the absence of rifampicin at 42.2°C in DM25, Target modification, DNA-directed RNA polymerase subunit beta RpoB	Escherichia coli, Mycobacterium tuberculosis, Shigella sonnei	rifampicin\|rifabutin\|rifapentinerifampicinrifamycins	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	I572L	-	Target modification, DNA-directed RNA polymerase subunit beta RpoB	Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis, Shigella sonnei	rifampicinrifamycins	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase B subunit	I572M	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB beta-subunit of RNA polymerase	I572N	T1716A	Target modification, DNA-directed RNA polymerase subunit beta RpoB	Escherichia coli, Shigella sonnei	rifampicinrifamycins	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB beta-subunit of RNA polymerase	I572S	-	-	Escherichia coli	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	I572V	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB Beta-subunit of RNA polymerase	I586L	-	single resistance variant	Helicobacter pylori	rifampicin\|rifabutinrifampicin	Card DatabaseReslit	Confirmed
rpoB Beta-subunit of RNA polymerase	I586N	-	single resistance variant	Helicobacter pylori	rifampicin\|rifabutinrifampicin	Card DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	I65T	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate