Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase subunit β	S444N	-	-	Corynebacterium urealyticum	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S445L	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB DNA-directed RNA polymerase subunit beta	S446P	-	-	Cutibacterium avidum	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S447L	-	-	Mycobacterium smegmatis, Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S450A	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseReslit	Confirmed
rpoB	S450C	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase beta subunit	S450F	TCG->TTC	single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB	S450G	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase beta subunit	S450L	C1351T TCA->CTA TCC->CTC AGC->CTC A1351T T1348C C1349T TCA -> CTG T1350C AGT->CTT C1350T C1348T	confers rifampicin resistance, disrupts a key intermolecular hydrogen bond between serine and RIF and introduces a hydrophobic leucine residue that causes steric hindrance, decreased drug binding affinity, increased IC 50 of both rifamycins, The rpoB S450L mutation is located in the 81-bp RIF resistance–determining region (RRDR) of the rpoB gene, multiple resistance variants, single resistance variant	Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium kansasii, Mycobacterium smegmatis, Rhodothermus marinus, Escherichia coli, Mycobacterium bovis, Staphylococcus aureus	rifampicincapreomycinrifampicin\|rifabutin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB	S450M	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established