Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase beta subunit	S441S	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB	S441Ter	-	nonsense mutation	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB	S441V	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB	S441Var	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase beta subunit	S441W	AGC->TGG	single resistance variant	Mycobacterium tuberculosis, Mycobacterium smegmatis	capreomycinrifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase β subunit	S442F	C1325T	DNA-directed RNA polymerase subunit beta RpoB	Streptomyces albus, Corynebacterium diphtheriae	rifampicinrifamycins	Reference Gene CatalogReslit	Confirmed
rpoB	S442N	-	DNA-directed RNA polymerase subunit beta RpoB	Corynebacterium diphtheriae	rifamycins	Reference Gene Catalog	Established
rpoB RNA polymerase β subunit	S442Y	C1325A	The mutation causes a serine to tyrosine substitution at position 442, leading to a more hydrophobic environment in the rifampin binding pocket, which reduces the effectiveness of rifampin., DNA-directed RNA polymerase subunit beta RpoB	Streptomyces albus, Corynebacterium diphtheriae	rifampicinrifamycins	Reference Gene CatalogReslit	Confirmed
rpoB DNA-directed RNA polymerase subunit beta	S443F	-	-	Rhodococcus equi	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S444F	C1330T	-	Corynebacterium diphtheriae, Corynebacterium urealyticum	rifampicin	Reslit	Candidate