Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
sgm aminoglycoside resistance methyltransferase	N179A	-	wild-type phenotype	E. coli	aminoglycosides	Reslit	Candidate
sgm aminoglycoside resistance methyltransferase	R236A	-	abolished MT activity	E. coli	aminoglycosides	Reslit	Candidate
sigA primary sigma factor	G336C	-	reduces susceptibility to vancomycin and fosfomycin by altering promoter recognition.	Bacillus subtilis	vancomycin\|fosfomycin	Reslit	Candidate
sigA sigma factor subunit of RNA polymerase	R515H	-	disrupting, knocking out, or mutating the gene causes SUSCEPTIBILITY	Mycobacterium smegmatis	spectinomycin\|tetracycline\|clarithromycin	Reslit	Candidate
sigE Extracytoplasmic function sigma factor	V166L	-	The V166L substitution falls within the SigE σ 2 /σ 4 linker, influencing transcription initiation.	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
sigI	K270Q	-	single resistance variant	Mycobacterium tuberculosis	isoniazid	Card Database	Established
sigX transcriptional regulator	Q35H	-	-	Pseudomonas aeruginosa	ceftazidime	Reslit	Candidate
silS regulatory protein	-	-103ins	-	Escherichia coli	ampicillin\|ciprofloxacin	Reslit	Candidate
slt soluble lytic murein transglycosylase	-	C1423T	-	-	imipenem	Reslit	Candidate
slt lytic transglycosylase	E505A	G1514A	-	Escherichia coli	vancomycin	Reslit	Candidate