Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
grlA topoisomerase IV A subunit	A116E	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones, Target modification	Staphylococcus aureus	quinolonesfluoroquinolonesciprofloxacin+1 more	ResFinder DatabaseReslit	Confirmed
grlA topoisomerase IV A subunit	A116P	G348C	-	Staphylococcus aureus	quinolonesciprofloxacin	Reslit	Supported
grlA DNA topoisomerase IV subunit A	A116V	-	-	Staphylococcus aureus	fluoroquinolones	Reslit	Candidate
grlA topoisomerase IV A subunit	A176T	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	quinolonesciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	A48T	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones, Target modification	Staphylococcus aureus	ciprofloxacin\|levofloxacin\|moxifloxacinciprofloxacin	ResFinder DatabaseReslit	Confirmed
grlA DNA gyrase subunit A	C239A	-	-	Staphylococcus epidermidis	fluoroquinolones	Reslit	Candidate
grlA topoisomerase IV A subunit	D69Y	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	quinolonesciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
grlA	D84G	-	DNA topoisomerase GrlA	Staphylococcus intermedius	quinolones	Reference Gene Catalog	Established
grlA	D84H	-	DNA topoisomerase GrlA	Staphylococcus intermedius	quinolones	Reference Gene Catalog	Established
grlA topoisomerase IV A subunit	D84N	-	DNA topoisomerase GrlA	Staphylococcus pseudintermedius, Staphylococcus intermedius	enrofloxacinciprofloxacinfluoroquinolones+1 more	Reference Gene CatalogReslit	Confirmed