Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit A	D86N	G257A	-	Helicobacter pylori	fluoroquinoloneslevofloxacinciprofloxacin	Reslit	Supported
gyrA DNA gyrase subunit A	D87A	-	reduced susceptibility to ciprofloxacin, likely responsible for the acquired resistance to fluoroquinolones, Target modification, DNA gyrase subunit A GyrA	Salmonella Enteritidis, Klebsiella pneumoniae, Escherichia coli, Salmonella enterica, Klebsiella oxytoca, Enterobacteriaceae, Gallibacterium anatis	ciprofloxacinfluoroquinolonesciprofloxacin\|levofloxacin+6 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D87E	G261A	decreased affinity for ciprofloxacin	Escherichia coli, Corynebacterium macginleyi, Salmonella, Pseudomonas aeruginosa, Campylobacter, Neisseria gonorrhoeae, Neisseria meningitidis	nalidixic acidlevofloxacinciprofloxacin+3 more	Reslit	Supported
gyrA DNA gyrase subunit A	D87F	-	-	-	ciprofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	D87G	GAT->GGT A261G GAT->GGA A260G G260G	mutations in QRDR region, confers resistance, reduced ciprofloxacin binding affinity, mutation in quinolone resistance-determining region, Known effect : resistance to fluoroquinolones, destabilizing, alter the characteristics of the binding pocket resulting in the loss of crucial molecular interactions and consequently decrease the binding affinity of fluoroquinolones with the target protein, reduced susceptibility to fluoroquinolones, deleterious, Target modification, single resistance variant, multiple resistance variants, DNA gyrase subunit A GyrA	Klebsiella oxytoca, Escherichia coli, Salmonella enterica, Salmonella, Pseudomonas aeruginosa, Shigella flexneri, Shigella sonnei, Klebsiella pneumoniae, Acinetobacter baumannii, Salmonella Typhi, Salmonella Typhimurium, Salmonella Kentucky, Salmonella Enteritidis, E. coli, Salmonella typhi, Mannheimia haemolytica, Chryseobacterium indologenes, Salmonella Choleraesuis, Salmonella Dublin, Salmonella Typhimium, Shigella spp., Pasteurella multocida, Salmonella Gallinarum, Enterobacteriaceae, Shigella dysenteriae, Gallibacterium anatis, Salmonella Infantis, Salmonella typhimurium, Helicobacter pylori, Citrobacter freundii, Enterobacter cloacae	ciprofloxacinofloxacin\|ciprofloxacin\|trovafloxacin\|sparfloxacinquinolones+25 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D87H	G260C	deleterious, Target modification, single resistance variant, multiple resistance variants, DNA gyrase subunit A GyrA	Enterobacter cloacae, Corynebacterium macginleyi, Mannheimia haemolytica, Riemerella anatipestifer, Brevundimonas brasiliensis, Enterobacteriaceae, Escherichia coli, Burkholderia dolosa, Pseudomonas aeruginosa, Klebsiella pneumoniae	ciprofloxacinciprofloxacin\|levofloxacinfluoroquinolones+5 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA	D87K	-	Target modification, DNA gyrase subunit A GyrA	Salmonella enterica	nalidixic acid\|ciprofloxacinquinolones	Reference Gene CatalogResFinder Database	Confirmed
gyrA DNA gyrase subunit A	D87N	GAT->AAT G260A G261A G259A	quinolone resistance, confers resistance, mutations in gyrA ... confer resistance to ciprofloxacin, reduced ciprofloxacin binding affinity, confers resistance to ciprofloxacin, stabilizing, reduced susceptibility to fluoroquinolones, alterations in gyrase, resistance to ciprofloxacin, mutation in the gyrA gene giving the D87N substitution in the amino acid sequence associated with quinolone resistance, mutations in gyrA (D87N) and a total of 24 missense mutations in the PmrAB and PhoPQ systems were found within the chromosome of S . Typhimurium WW012, deleterious, reduced binding affinity, mutations in quinolone resistance determining regions (gyrA or parC), Target modification, multiple resistance variants, single resistance variant, DNA gyrase subunit A GyrA	Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Salmonella enterica, Escherichia coli, Salmonella, Pseudomonas aeruginosa, Shigella flexneri, Shigella sonnei, Acinetobacter baumannii, Salmonella Typhi, Salmonella Typhimurium, E. coli, Glaesserella parasuis, Salmonella Kentucky, Corynebacterium macginleyi, Yersinia enterocolitica, enterotoxigenic Escherichia, Salmonella Enteritidis, Salmonella typhi, Mannheimia haemolytica, Escherichia spp., Enterobacter spp., Klebsiella spp., Salmonella spp., Salmonella Dublin, Shigella dysenteriae, Salmonella Paratyphi, Shigella spp., Salmonella 4,[5],12:i:-, Mycoplasma genitalium, Salmonella Gallinarum, Salmonella Isangi, Enterobacteriaceae, Shigella boydii, Salmonella pullorum, Serratia marcescens, Vibrio cholerae	ciprofloxacinquinolonesciprofloxacin\|nalidixic acid+34 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D87R	-	-	-	ciprofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	D87S	-	-	-	ciprofloxacin	Reslit	Candidate