Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit A	D87T	G261A	-	Salmonella enterica	nalidixic acid\|pefloxacin	Reslit	Supported
gyrA DNA gyrase subunit A	D87V	-	Target modification, single resistance variant, DNA gyrase subunit A GyrA	Salmonella enterica, Salmonella Typhi, Escherichia coli	ciprofloxacinciprofloxacin\|ofloxacinnalidixic acid+3 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D87X	-	-	Escherichia coli	ciprofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	D87Y	GAT->TAT G259T G260T	confers resistance, mutations in gyrA confer resistance to ciprofloxacin, stabilizing, alter the characteristics of the binding pocket resulting in the loss of crucial molecular interactions and consequently decrease the binding affinity of fluoroquinolones with the target protein, reduced susceptibility to fluoroquinolones, resistance to ciprofloxacin, harbored mutations gyrA (S83F), gyrA (D87Y), and parC (S80I) associated with resistance to quinolones, reduced susceptibility, mutations in GyrA (S83Y, S83F, D87G, D87N, and D87Y) and ParC (S80I), deleterious, Target modification, multiple resistance variants, single resistance variant, DNA gyrase subunit A GyrA	Klebsiella pneumoniae, Escherichia coli, Salmonella enterica, Acinetobacter baumannii, Pseudomonas aeruginosa, Salmonella Typhi, Salmonella Typhimurium, Glaesserella parasuis, Salmonella, Salmonella Enteritidis, Clostridium perfringens, Salmonella Kentucky, Corynebacterium macginleyi, Yersinia enterocolitica, Shewanella algae, Francisella novicida, Francisella tularensis, E. coli, Shigella sonnei, Shigella flexneri, Shigella boydii, Mannheimia haemolytica, Flavobacterium oreochromis, Flavobacterium covae, Flavobacterium davisii, Salmonella Dublin, Salmonella 4,[5],12:i:-, Salmonella Gallinarum, Piscirickettsia salmonis, Helicobacter pylori, Salmonella 4,5, Enterobacteriaceae, Salmonella typhi, Burkholderia pseudomallei	ciprofloxacinquinolonesnalidixic acid+21 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D88G	-	DNA gyrase subunit A GyrA	Haemophilus influenzae, non-typeable Haemophilus	ciprofloxacin\|levofloxacin\|moxifloxacinlevofloxacin\|ciprofloxacinquinolones	Reference Gene CatalogReslit	Confirmed
gyrA	D88N	-	DNA gyrase subunit A GyrA	Haemophilus influenzae	quinolones	Reference Gene Catalog	Established
gyrA DNA gyrase subunit A	D88Y	G262T	DNA gyrase subunit A GyrA	Haemophilus influenzae, Haemophilus parainfluenzae	ciprofloxacinquinolones	Reference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	D89A	-	-	Mycobacterium tuberculosis	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase	D89G	-	single resistance variant	Mycobacterium tuberculosis	moxifloxacin\|levofloxacinofloxacin\|levofloxacin\|moxifloxacinfluoroquinolones	Card DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D89N	G266A	single resistance variant	Mycobacterium tuberculosis	fluoroquinolonesmoxifloxacin\|levofloxacinofloxacin\|levofloxacin\|moxifloxacin+2 more	Card DatabaseResFinder DatabaseReslit	Confirmed