Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit A	D94N	G281A G280A G281T G282A	emerging resistance to the fluoroquinolones was associated with 16- and 64-fold elevated levofloxacin (2–8 mg/L) and moxifloxacin (1–2 mg/L) MICs, respectively, resulting from the D94G/N and A90V variants in the gyrA gene, alter the protein at codons 94, replacing aspartic acid with asparagine and tyrosine, single resistance variant	Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium aurum	fluoroquinolonesofloxacinofloxacin\|moxifloxacin\|ciprofloxacin\|levofloxacin+13 more	Card DatabaseResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D94S	-	-	Mycobacterium tuberculosis	fluoroquinolones	Reslit	Candidate
gyrA	D94T	-	single resistance variant	Mycobacterium tuberculosis	fluoroquinolones	Card Database	Established
gyrA DNA gyrase subunit A	D94V	A281T	single resistance variant	Mycobacterium tuberculosis	fluoroquinolonesofloxacinofloxacin\|moxifloxacin\|levofloxacin+1 more	Card DatabaseResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D94X	-	-	-	ofloxacinfluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	D94Y	GAT->TAT G281C G280T	alter the protein at codons 94, replacing aspartic acid with asparagine and tyrosine, single resistance variant	Mycobacterium tuberculosis, Mycobacterium smegmatis, Corynebacterium diphtheriae, Mycobacterium aurum, Corynebacterium urealyticum	fluoroquinolonesofloxacinofloxacin\|moxifloxacin\|ciprofloxacin\|levofloxacin+10 more	Card DatabaseResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D95A	-	Reduced quinolone binding to DNA gyrase, DNA gyrase subunit A GyrA	Neisseria gonorrhoeae, Neisseria meningitidis	ciprofloxacinfluoroquinolonesquinolones	Reference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	D95E	-	-	Ureaplasma urealyticum	ciprofloxacinfluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	D95G	G285C	reduced susceptibility to ciprofloxacin, decreased affinity for ciprofloxacin, enhanced the ability of zoliflodacin and other SPTs to induce gyrase-mediated DNA cleavage, single resistance variant, DNA gyrase subunit A GyrA	Neisseria gonorrhoeae, Bartonella bacilliformis, Escherichia coli, Pseudomonas aeruginosa, Campylobacter, Neisseria meningitidis, Mycobacterium avium	ciprofloxacinfluoroquinolonesciprofloxacin\|levofloxacin+3 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D95H	-	-	-	fluoroquinolones	Reslit	Candidate