Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit A	D91Y	G271T	confer resistance to LVX, single resistance variant, multiple resistance variants, DNA gyrase subunit A GyrA	Corynebacterium striatum, Helicobacter pylori, Corynebacterium spp., Corynebacterium jeikeium, Corynebacterium urealyticum, Campylobacter fetus	ciprofloxacin\|levofloxacinlevofloxacin\|moxifloxacin\|ciprofloxacinlevofloxacin+5 more	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	D92G	-	-	Helicobacter pylori	levofloxacin	Reslit	Candidate
gyrA	D93A	-	DNA gyrase subunit A GyrA	Corynebacterium diphtheriae	quinolones	Reference Gene Catalog	Established
gyrA	D93Y	-	DNA gyrase subunit A GyrA	Corynebacterium diphtheriae	quinolones	Reference Gene Catalog	Established
gyrA DNA gyrase subunit A	D94A	GAT->GCT G280A GAT->GCC A281C GAT->GCA G282A	alter the protein at codons 94, replacing aspartic acid with alanine, single resistance variant	Mycobacterium tuberculosis, Mycobacterium smegmatis, Corynebacterium urealyticum	fluoroquinolonesofloxacinofloxacin\|moxifloxacin\|ciprofloxacin\|levofloxacin+16 more	Card DatabaseResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D94D	-	-	Mycobacterium tuberculosis	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	D94E	T284A	-	-	ofloxacinfluoroquinolones	Reslit	Supported
gyrA DNA gyrase subunit A	D94F	-	-	Mycobacterium tuberculosis	ofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	D94G	G280A GAT->GGT GAC->GGC GAC-GGC GGA->GGA G280C GAT -> GGG G281A A282G A281G G282A	mutations in the gyrA and/or gyrB subunit of DNA gyrase lead to fluoroquinolone resistance, disrupts the binding of orbifloxacin with protein GyrA, disrupting the water-metal ion bridge, loss of an acid (acetyl) group, thus preventing the acid-base interaction between the LVX amino group and the Asp acid group at the catalytic site, emerging resistance to the fluoroquinolones was associated with 16- and 64-fold elevated levofloxacin (2–8 mg/L) and moxifloxacin (1–2 mg/L) MICs, respectively, resulting from the D94G/N and A90V variants in the gyrA gene, alter the protein at codons 94, replacing aspartic acid with glycine, single resistance variant, multiple resistance variants	Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium smegmatis, Mycobacterium aurum	ofloxacinfluoroquinolonesofloxacin\|moxifloxacin\|ciprofloxacin\|levofloxacin+22 more	Card DatabaseResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	D94H	GAT->CAT	disrupting the water-metal ion bridge, single resistance variant	Mycobacterium tuberculosis, Mycobacterium smegmatis	fluoroquinolonesciprofloxacin\|levofloxacin\|moxifloxacin\|gatifloxacinofloxacin\|levofloxacin\|sparfloxacin+11 more	Card DatabaseResFinder DatabaseReslit	Confirmed