Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit A	S81L	TCC->CTC TCA->CTA	lower the affinity for quinolone, resistance, mutations in gyrA and parC genes, confers high-level resistance to fluoroquinolones, single resistance variant, DNA gyrase subunit A GyrA	Streptococcus pneumoniae, Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus oralis, Streptococcus mitis, Neisseria gonorrhoeae, A. baumannii, Acinetobacter pittii, Acinetobacter nosocomialis, Non-baumannii Acinetobacter	clinafloxacin\|ciprofloxacin\|trovafloxacinciprofloxacinfluoroquinolones+8 more	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	S81N	-	-	Streptococcus agalactiae	norfloxacin	Reslit	Candidate
gyrA DNA gyrase subunit	S81V	-	-	Streptococcus pneumoniae	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	S81Y	T243A	-	Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus agalactiae	clinafloxacin\|ciprofloxacin\|trovafloxacinciprofloxacin\|garenoxacin\|sparfloxacin\|trovafloxacingemifloxacin\|trovafloxacin\|sparfloxacin\|ciprofloxacin+9 more	Reslit	Supported
gyrA DNA gyrase subunit A	S826T	-	-	-	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	S82F	-	-	Bacteroides	ampicillinfluoroquinolones	Reslit	Candidate
gyrA DNA gyrase A subunit	S82L	-	-	Bacteroides fragilis	ciprofloxacin\|levofloxacin\|moxifloxacin\|clinafloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	S82P	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	Candidate
gyrA DNA gyrase A protein	S83A	G248A AGC->GCC	reduced fluoroquinolone susceptibility, Target modification, DNA gyrase subunit A GyrA	Escherichia coli, Nocardia cyriacigeorgica, Nocardia abscessus, Flavobacterium oreochromis, Flavobacterium covae, Flavobacterium davisii, N. cyriacigeorgica, Salmonella enterica, Klebsiella pneumoniae	ciprofloxacinfluoroquinolonesnalidixic acid\|flumequine\|enrofloxacin\|ciprofloxacin\|moxifloxacin+8 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	S83E	-	-	-	ciprofloxacin	Reslit	Candidate