Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit A	S83Y	G248T TCA->TAC TCA -> TAT AGT->TAT TCT->TAC TCA->TAT TCC->TAC C248A T249A	reduced susceptibility to ciprofloxacin, mutations in QRDR region, confers resistance, mutations in gyrA ... confer resistance to ciprofloxacin, reduced ciprofloxacin binding affinity, alter the characteristics of the binding pocket resulting in the loss of crucial molecular interactions and consequently decrease the binding affinity of fluoroquinolones with the target protein, reduced susceptibility to fluoroquinolones, alterations in gyrase, reduced susceptibility, mutations in gyrA confer resistance to ciprofloxacin, Target modification, DNA gyrase subunit A GyrA	Klebsiella pneumoniae, Enterobacter aerogenes, Salmonella enterica, Salmonella Typhi, Salmonella Typhimurium, E. coli, Glaesserella parasuis, Salmonella, Escherichia coli, Salmonella Enteritidis, Salmonella typhi, Mannheimia haemolytica, Escherichia spp., Enterobacter spp., Klebsiella spp., Salmonella spp., Chryseobacterium indologenes, Salmonella Dublin, Salmonella 4,[5],12:i:-, Enterococcus cecorum, Salmonella Derby, Gallibacterium anatis, Salmonella Paratyphi, Salmonella typhimurium, Enterococcus faecalis, Enterococcus faecium, Enterobacter cloacae	ciprofloxacinciprofloxacin\|nalidixic acidciprofloxacin\|ofloxacin+17 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	S84A	-	Target modification, DNA gyrase subunit A GyrA	Staphylococcus aureus, Staphylococcus pseudintermedius	levofloxacin\|moxifloxacinfluoroquinolonesciprofloxacin+1 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase A	S84F	-	-	Staphylococcus epidermidis, Streptococcus pneumoniae, Haemophilus parainfluenzae, non-typeable Haemophilus, Staphylococcus cohnii, Staphylococcus condimenti, Enterococcus faecalis, Salmonella pullorum	ciprofloxacin\|ofloxacin\|gatifloxacin\|moxifloxacinfluoroquinoloneslevofloxacin\|gatifloxacin\|moxifloxacin\|tosufloxacin+5 more	Reslit	Supported
gyrA DNA gyrase subunit A	S84I	-	-	Enterococcus faecalis, Corynebacterium sp.	ciprofloxacin\|norfloxacinmoxifloxacin\|ofloxacinciprofloxacin\|enrofloxacin\|marbofloxacin\|tulathromycin+1 more	Reslit	Supported
gyrA DNA gyrase A subunit	S84K	-	-	Staphylococcus aureus, Streptococcus pneumoniae	quinolones	Reslit	Candidate
gyrA DNA gyrase A subunit	S84L	T252C TCA -> TTG T251C AGT->TTT TCA->CTA C251T AGC->CTC G251T	reduced potency of ciprofloxacin, decreased binding affinity of ciprofloxacin to its target, confers resistance, resistance, mutation in GyrA confers resistance to ciprofloxacin, fluoroquinolone resistance, mutations in QRDRs, Target modification, single resistance variant, DNA gyrase subunit A GyrA	Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus simulans, Staphylococcus aureus, Staphylococcus pseudintermedius, Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus agnetis, Staphylococcus chromogenes, Staphylococcus arlettae, Staphylococcus lentus, Moraxella catarrhalis, Haemophilus quentini, Haemophilus haemolyticus, Staphylococcus sciuri, Staphylococcus cohnii, Staphylococcus condimenti, Staphylococcus gallinarum, Staphylococcus saprophyticus, Staphylococcus ureilyticus, Staphylococcus warneri, Staphylococcus xylosus, S. haemolyticus	ciprofloxacinquinolonesfluoroquinolones+20 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	S84P	-	-	Mycoplasma salivarium	quinoloneslevofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	S84R	-	-	Enterococcus faecalis, Enterococcus faecium	levofloxacinmoxifloxacin\|ofloxacinciprofloxacin	Reslit	Supported
gyrA	S84V	-	DNA gyrase subunit A GyrA	Staphylococcus aureus	quinolones	Reference Gene Catalog	Established
gyrA	S84W	-	DNA gyrase subunit A GyrA	Staphylococcus pseudintermedius	quinolones	Reference Gene Catalog	Established