Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit a	S90A	-	-	Staphylococcus aureus	ciprofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	S90C	-	-	Shigella sonnei	ciprofloxacin\|ofloxacin\|levofloxacin	Reslit	Candidate
gyrA DNA gyrase A subunit	S90F	TCA->TTC T268C	-	Corynebacterium diphtheriae	fluoroquinolonesciprofloxacin	Reslit	Supported
gyrA DNA gyrase subunit A	S90L	-	-	Mycobacterium aurum	levofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	S90P	-	-	Mycobacterium tuberculosis	levofloxacin\|moxifloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	S90V	-	-	Corynebacterium urealyticum	levofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	S90Y	-	-	Bacteriovorax sp.	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	S91A	-	-	Mycobacterium tuberculosis	fluoroquinolones	ResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	S91F	AGC->TTC G272T	confers resistance to fluoroquinolones, decrease the affinity between ciprofloxacin molecule and its binding sites, reduced susceptibility to ciprofloxacin, Reduced quinolone binding to DNA gyrase, decreased fluoroquinolone binding, confers resistance, enhanced the ability of zoliflodacin and other SPTs to induce gyrase-mediated DNA cleavage, single resistance variant, DNA gyrase subunit A GyrA	Neisseria gonorrhoeae, Neisseria bacilliformis, Neisseria lactamica, Neisseria cinerea, Neisseria elongata, Neisseria polysaccharea, Neisseria bergeri, Neisseria oralis, Neisseria mucosa, Neisseria subflava, Neisseria zoodegmatis, Neisseria macacae, Neisseria meningitidis	fluoroquinolonesciprofloxacin\|gatifloxacin\|levofloxacin\|ofloxacinciprofloxacin+4 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA	S91I	-	DNA gyrase subunit A GyrA	Neisseria gonorrhoeae	quinolones	Reference Gene Catalog	Established