Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit A	T83Y	-	-	Enterobacteriaceae	ciprofloxacin\|norfloxacin\|ofloxacin\|levofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	T84I	-	confers resistance to fluoroquinolones	Helicobacter cinaedi	ciprofloxacin\|levofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	T85I	-	-	Chromobacterium violaceum, Aliarcobacter butzleri	nalidixic acid\|ciprofloxacin\|norfloxacin\|levofloxacinciprofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	T86A	C257G	mutations in the DNA gyrase A (GyrA) region at multiple positions, Target modification, DNA gyrase subunit A GyrA	Campylobacter jejuni, Campylobacter coli	nalidixic acidciprofloxacin\|nalidixic acidfluoroquinolones+3 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	T86I	C257T T257A	increased resistance, mutations in the DNA gyrase A (GyrA) region at multiple positions, decrease the sensitivity of Campylobacter spp. to quinolones, confers resistance to ciprofloxacin, confers resistance to (fluoro-)quinolones, decreased affinity for ciprofloxacin, increased resistance to FQs, relaxation of DNA supercoiling, confers high-level resistance to ciprofloxacin, confers resistance to fluoroquinolones, confers high-level resistance to quinolones, Target modification, single resistance variant, DNA gyrase subunit A GyrA	Campylobacter jejuni, Campylobacter coli, C. coli, Campylobacter spp., Campylobacter fetus, E. coli, Campylobacter upsaliensis, Erysipelothrix rhusiopathiae, Campylobacter, Arcobacter butzleri, Escherichia coli, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis	fluoroquinolonesciprofloxacin\|nalidixic acidnalidixic acid\|ciprofloxacin\|levofloxacin+8 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	T86K	C257A	Target modification, single resistance variant, DNA gyrase subunit A GyrA	Campylobacter jejuni, Campylobacter coli, Erysipelothrix rhusiopathiae	ciprofloxacin\|nalidixic acidfluoroquinolonesciprofloxacin+3 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	T86V	C257G	confers resistance to (fluoro-)quinolones, Target modification, DNA gyrase subunit A GyrA	Campylobacter jejuni, Campylobacter lari, Campylobacter insulaenigrae, Campylobacter subantarcticus, Campylobacter volucris, Campylobacter coli	ciprofloxacin\|nalidixic acidfluoroquinolonesnalidixic acid\|ciprofloxacin+1 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	T872A	-	-	Acinetobacter baumannii	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	T878A	-	-	Yersinia enterocolitica	ciprofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	T87I	-	single resistance variant	Campylobacter fetus, Helicobacter pylori	ciprofloxacin\|enrofloxacinfluoroquinolones	Card DatabaseReslit	Confirmed