Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase	T82A	-	multiple resistance variants, single resistance variant, DNA gyrase subunit A GyrA	Clostridioides difficile	ciprofloxacinfluoroquinolonesquinolones	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	T82I	C245T CCT->ATT GAA->ATA	confers resistance, increased fitness, fluoroquinolone resistance, single resistance variant, DNA gyrase subunit A GyrA	Clostridium difficile, Clostridioides difficile, Clostridioides (Clostridium)	ciprofloxacin\|moxifloxacinmoxifloxacin\|ciprofloxacin\|gatifloxacin\|levofloxacinciprofloxacin\|moxifloxacin\|levofloxacin+12 more	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	T82V	-	single resistance variant, DNA gyrase subunit A GyrA	Clostridium difficile, Clostridioides difficile	ciprofloxacin\|moxifloxacinfluoroquinolonesquinolones	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	T831K	-	-	-	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	T83A	-	DNA gyrase subunit A GyrA	Flavobacterium psychrophilum, Pseudomonas aeruginosa	oxolinic acid\|enrofloxacinciprofloxacinquinolones	Reference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	T83F	-	-	Enterobacteriaceae	ciprofloxacin\|norfloxacin\|ofloxacin\|levofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	T83I	C249T G248A C250T C248T TAT->ATT	mutations in gyrA confer resistance to ciprofloxacin, reduction of the binding affinity of fluoroquinolones to DNA gyrase leading to reduced susceptibility, mutation leads to decreased susceptibility to fluoroquinolones, stabilizing, confers quinolone resistance, target modification, mutations in gyrA that result in the loss of function of DNA gyrase, leading to resistance to fluoroquinolones, amino acid substitution, decreased affinity for ciprofloxacin, reduced binding affinity, associated with resistance to fluoroquinolones, single resistance variant, multiple resistance variants, DNA gyrase subunit A GyrA	Clostridium difficile, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, Francisella novicida, Neisseria subflava, Francisella tularensis, Pseudomonas putida, Legionella pneumophila, Campylobacter, Neisseria gonorrhoeae, Neisseria meningitidis, Enterobacteriaceae, Salmonella Typhimurium, Salmonella Enteritidis, Burkholderia dolosa, Clostridioides difficile, Burkholderia pseudomallei, Citrobacter freundii, Klebsiella oxytoca	moxifloxacinciprofloxacinciprofloxacin\|garenoxacin+14 more	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	T83L	-	-	Enterobacteriaceae	ciprofloxacin\|norfloxacin\|ofloxacin\|levofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	T83R	-	-	Enterobacteriaceae	ciprofloxacin\|norfloxacin\|ofloxacin\|levofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	T83V	-	-	Pseudomonas aeruginosa	quinolones	Reslit	Candidate