Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrB	D409N	-	single resistance variant	Clostridium ljungdahlii	fluoroquinolones	Card Database	Established
gyrB DNA gyrase subunit B	D420N	-	-	Salmonella enterica	nalidixic acid	Reslit	Candidate
gyrB DNA gyrase subunit B	D423N	-	confers resistance to fluoroquinolones	Helicobacter cinaedi	ciprofloxacin\|levofloxacin	Reslit	Candidate
gyrB DNA gyrase subunit B	D426A	-	-	-	moxifloxacin	Reslit	Candidate
gyrB DNA gyrase subunit B	D426N	G1277A	Target modification, single resistance variant, DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Clostridium difficile, Escherichia coli, E. coli, Clostridioides difficile, Salmonella spp., Proteus mirabilis, Capnocytophaga spp., Clostridium perfringens, S. aureus, S. pneumoniae, Clostridioides (Clostridium), Salmonella enterica, Clostridium ljungdahlii	ciprofloxacin\|moxifloxacinmoxifloxacin\|ciprofloxacin\|gatifloxacin\|levofloxacinmoxifloxacin\|ciprofloxacin\|levofloxacin\|gatifloxacin+7 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrB DNA gyrase subunit B	D426V	GAT->GTG	single resistance variant, DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Clostridium difficile, Clostridium ljungdahlii, Clostridioides difficile	moxifloxacin\|ciprofloxacin\|gatifloxacin\|levofloxacinmoxifloxacin\|levofloxacinmoxifloxacin+4 more	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrB DNA gyrase subunit B	D427N	-	-	-	levofloxacin\|moxifloxacin	Reslit	Candidate
gyrB DNA gyrase subunit B	D429N	G1285A	increased zoliflodacin MICs, increased MICs of zoliflodacin, single resistance variant, DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Neisseria gonorrhoeae, Neisseria subflava	zoliflodacin	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrB DNA gyrase B subunit	D429V	-	-	Neisseria gonorrhoeae	zoliflodacin	Reslit	Candidate
gyrB DNA gyrase subunit B	D432N	-	-	-	ciprofloxacin	Reslit	Candidate