Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrB DNA gyrase subunit B	E483D	-	DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Pseudomonas aeruginosa	ciprofloxacin\|levofloxacin\|ofloxacinquinolones	Reference Gene CatalogReslit	Confirmed
gyrB DNA gyrase subunit B	E486K	-	-	Francisella tularensis	fluoroquinolones	Reslit	Candidate
gyrB DNA gyrase subunit B	E487K	-	-	Francisella tularensis	fluoroquinolones	Reslit	Candidate
gyrB DNA gyrase subunit B	E490G	-	-	Staphylococcus simulans	ciprofloxacin	Reslit	Candidate
gyrB DNA gyrase subunit B	E501D	-	single resistance variant	Mycobacterium tuberculosis	levofloxacinmoxifloxacinrifampicin+1 more	Card DatabaseResFinder DatabaseReslit	Confirmed
gyrB DNA gyrase subunit B	E501V	-	single resistance variant	Mycobacterium tuberculosis	ofloxacin\|moxifloxacin\|ciprofloxacin\|levofloxacinofloxacin\|moxifloxacin\|ciprofloxacinfluoroquinolones	Card DatabaseResFinder DatabaseReslit	Confirmed
gyrB	E502Q	-	single resistance variant	Ureaplasma urealyticum	fluoroquinolones	Card Database	Established
gyrB	E504V	-	single resistance variant	Mycobacterium leprae	fluoroquinolones	Card Database	Established
gyrB DNA gyrase subunit B	E512D	G1537T	-	Mycobacterium tuberculosis	fluoroquinolones	Reslit	Candidate
gyrB DNA gyrase subunit B	E540D	A1622T GAG->GAT	confers resistance to moxifloxacin, confers resistance to quinolones	Mycobacterium tuberculosis	ofloxacinfluoroquinolonesmoxifloxacin+2 more	Reslit	Supported