Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mcr-2 Phosphoethanolamine transferase	H476R	-	The mutation H476R in MCR-2 was shown to partially confer colistin resistance, as evidenced by the presence of a specific peak for PPEA-1(4′)-lipid A in MALDI-TOF MS analysis.	Escherichia coli, Salmonella enterica	colistin	Reslit	Candidate
mcr-2 Phosphoethanolamine transferase	K331E	-	The mutation K331E in MCR-2 was shown to partially confer colistin resistance, as evidenced by the presence of a specific peak for PPEA-1(4′)-lipid A in MALDI-TOF MS analysis.	Escherichia coli, Salmonella enterica	colistin	Reslit	Candidate
mcr-2 Phosphoethanolamine transferase	N106A	-	The mutation N106A in MCR-2 was shown to partially confer colistin resistance, as evidenced by the presence of a specific peak for PPEA-1(4′)-lipid A in MALDI-TOF MS analysis.	Escherichia coli, Salmonella enterica	colistin	Reslit	Candidate
mcr-2 Phosphoethanolamine transferase	S328A	-	The mutation S328A in MCR-2 was shown to partially confer colistin resistance, as evidenced by the presence of a specific peak for PPEA-1(4′)-lipid A in MALDI-TOF MS analysis.	Escherichia coli, Salmonella enterica	colistin	Reslit	Candidate
mcr-2 Phosphoethanolamine transferase	T110A	-	The mutation T110A in MCR-2 was shown to partially confer colistin resistance, as evidenced by the presence of a specific peak for PPEA-1(4′)-lipid A in MALDI-TOF MS analysis.	Escherichia coli, Salmonella enterica	colistin	Reslit	Candidate
mcr-3 PEA transferase	T277A	ACC->GCC	decreased MCR-3 function	Escherichia coli, Aeromonas veronii, Salmonella enterica, Klebsiella pneumoniae, Citrobacter freundii	colistin	Reslit	Candidate
mcr-3 PEA transferase	T277S	ACC->AGC	decreased MCR-3 function	Escherichia coli, Aeromonas veronii, Salmonella enterica, Klebsiella pneumoniae, Citrobacter freundii	colistin	Reslit	Candidate
mdfA multidrug efflux pump	A42A	-	-	Escherichia coli	norfloxacin	Reslit	Candidate
mdfA multidrug resistance protein	E26K	-	-	Escherichia coli	phenicols	Reslit	Candidate
mdfA efflux pump component	V115A	-	-	Escherichia coli	phenicols	Reslit	Candidate