Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC topoisomerase IV subunit C	D86N	GAT->AAT	DNA topoisomerase IV subunit A ParC	Neisseria gonorrhoeae, Neisseria meningitidis	ciprofloxacin\|gatifloxacin\|levofloxacin\|ofloxacingepotidacin\|ciprofloxacinciprofloxacin+3 more	Reference Gene CatalogReslit	Confirmed
parC topoisomerase IV subunit C	D87E	-	-	Providencia rettgeri, Providencia stuartii	moxifloxacinfluoroquinolones	Reslit	Candidate
parC DNA gyrase subunit B	D87G	A262G G261A	single resistance variant	Mycoplasma genitalium, Escherichia coli, Salmonella enterica, Klebsiella pneumoniae, Salmonella Typhimurium, Mycoplasmoides genitalium	fluoroquinolonesofloxacin\|ciprofloxacinciprofloxacin\|ofloxacin\|levofloxacin+3 more	Card DatabaseReslit	Confirmed
parC DNA gyrase subunit A	D87H	-	single resistance variant	Mycoplasma genitalium, Mycoplasmoides genitalium	fluoroquinolonesmoxifloxacin	Card DatabaseReslit	Confirmed
parC topoisomerase IV subunit	D87N	G261A G260A G259A	single resistance variant	Escherichia coli, Mycoplasma genitalium, Salmonella enterica, S. Typhi, Salmonella Typhi, Salmonella Paratyphi, Mycoplasmoides genitalium	ciprofloxacin\|ofloxacin\|nalidixic acidciprofloxacinfluoroquinolones+4 more	Card DatabaseReslit	Confirmed
parC DNA gyrase subunit B	D87R	-	-	Mycoplasma genitalium	fluoroquinolones	Reslit	Candidate
parC topoisomerase IV subunit C	D87S	-	-	Neisseria gonorrhoeae, Salmonella enterica	fluoroquinolonesciprofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit C	D87V	-	-	-	moxifloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit C	D87Y	G259T G260T	single resistance variant	Escherichia coli, Mycoplasma genitalium, Salmonella enterica, Salmonella Typhi, Mycoplasmoides genitalium	ciprofloxacinfluoroquinolonesmoxifloxacin	Card DatabaseReslit	Confirmed
parC topoisomerase IV subunit C	D88S	-	-	Neisseria gonorrhoeae	fluoroquinolones	Reslit	Candidate