Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC DNA topoisomerase IV subunit C	E441Q	G1324A	-	-	ciprofloxacin	Reslit	Candidate
parC topoisomerase IV subunit C	E474K	G1420A	-	Streptococcus pneumoniae	ofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
parC DNA gyrase subunit C	E62K	G185A	-	Escherichia coli	enrofloxacinciprofloxacinciprofloxacin\|nalidixic acid+2 more	Reslit	Supported
parC topoisomerase IV subunit C	E640D	-	-	-	fluoroquinolones	Reslit	Candidate
parC topoisomerase IV subunit C	E80D	-	-	Enterobacter cloacae	fluoroquinolones	Reslit	Candidate
parC DNA topoisomerase IV subunit C	E80G	-	-	Escherichia coli	fluoroquinolones	Reslit	Candidate
parC topoisomerase IV	E80K	-	-	Escherichia coli	ciprofloxacin\|nalidixic acid	Reslit	Candidate
parC DNA topoisomerase IV subunit B	E82K	-	-	Francisella tularensis	fluoroquinolones	Reslit	Candidate
parC topoisomerase IV subunit A	E84A	-	Target modification, DNA topoisomerase IV subunit A ParC	Escherichia coli, Enterococcus faecalis, Enterococcus faecium	ciprofloxacinfluoroquinolonesnalidixic acid\|flumequine\|enrofloxacin\|ciprofloxacin\|moxifloxacin+5 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC DNA topoisomerase IV subunit C	E84G	GAG -> GGA GAA->GGG A253G	Target modification, single resistance variant, DNA topoisomerase IV subunit A ParC	Escherichia coli, Mycoplasma hyorhinis, E. coli, Klebsiella pneumoniae, Shigella sonnei, Salmonella typhi, Staphylococcus aureus, Salmonella enterica, Enterobacter cloacae, Salmonella Typhi, Salmonella Paratyphi	ciprofloxacinfluoroquinolonesnalidixic acid\|ciprofloxacin\|norfloxacin+11 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed