Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC DNA topoisomerase IV subunit A	E84K	GAA -> AAG G251A GAG -> AAA G252A	disrupts the water–metal ion bridge, Target modification, DNA topoisomerase IV subunit A ParC	Escherichia coli, Salmonella enterica, Enterococcus faecium, Acinetobacter baumannii, Salmonella, Mycoplasma hyorhinis, E. coli, Mycoplasma hominis, Staphylococcus aureus, Francisella novicida, Francisella tularensis, Salmonella typhi, Aeromonas caviae, Aeromonas hydrophila, Aeromonas sobria, S. Typhi, Enterococcus faecalis, Ureaplasma parvum, Ureaplasma urealyticum, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella Typhi, Mycoplasma salivarium	norfloxacin\|ciprofloxacinciprofloxacinnalidixic acid\|ciprofloxacin+17 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC	E84L	-	DNA topoisomerase IV subunit A ParC	Staphylococcus aureus	quinolones	Reference Gene Catalog	Established
parC topoisomerase IV subunit C	E84Q	-	-	Mycoplasma hyorhinis	fluoroquinolones	Reslit	Candidate
parC	E84R	-	Target modification, DNA topoisomerase IV subunit A ParC	Escherichia coli	nalidixic acid\|ciprofloxacinquinolones	Reference Gene CatalogResFinder Database	Confirmed
parC	E84T	-	Target modification, DNA topoisomerase IV subunit A ParC	Enterococcus faecalis, Enterococcus faecium	nalidixic acid\|ciprofloxacinquinolones	Reference Gene CatalogResFinder Database	Confirmed
parC topoisomerase IV subunit C	E84V	A251T A253T A252T G253T	Target modification, DNA topoisomerase IV subunit A ParC	Escherichia coli, E. coli, Klebsiella pneumoniae, Staphylococcus aureus	ciprofloxacinquinolonesfluoroquinolones+10 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC DNA topoisomerase IV subunit	E862Q	G2585C	-	Mycoplasma hominis	ofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit	E87K	-	-	Ureaplasma urealyticum, Ureaplasma parvum, Ureaplasma spp., Mycoplasma hominis	levofloxacinciprofloxacinfluoroquinolones+1 more	Reslit	Supported
parC DNA topoisomerase IV subunit A	E87Q	-	single resistance variant	Ureaplasma spp., Mycoplasma hominis, Ureaplasma parvum	levofloxacin\|moxifloxacinfluoroquinolones	Card DatabaseReslit	Confirmed
parC Topoisomerase IV subunit A	E88K	GAG->AAA	DNA topoisomerase IV subunit A ParC	Pseudomonas aeruginosa, Acinetobacter baumannii, Haemophilus influenzae, Pasteurella multocida, Neisseria gonorrhoeae	ciprofloxacinfluoroquinolonesenrofloxacin\|danofloxacin+2 more	Reference Gene CatalogReslit	Confirmed