Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC DNA topoisomerase IV subunit C	E89K	-	-	Mannheimia haemolytica	ciprofloxacinfluoroquinolones	Reslit	Candidate
parC topoisomerase IV subunit C	E91A	-	DNA topoisomerase IV subunit A ParC	Neisseria gonorrhoeae	fluoroquinolonesquinolones	Reference Gene CatalogReslit	Confirmed
parC DNA topoisomerase IV subunit C	E91F	-	-	Neisseria gonorrhoeae	ciprofloxacin	Reslit	Candidate
parC topoisomerase IV subunit C	E91G	G273A	High-level resistance when additional to gyrA S91P and gyrA D95N/G, single resistance variant, DNA topoisomerase IV subunit A ParC	Neisseria gonorrhoeae, Neisseria meningitidis	ciprofloxacinciprofloxacin\|garenoxacin\|sitafloxacindelafloxacin+2 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
parC topoisomerase IV subunit C	E91K	-	High-level resistance when additional to gyrA S91P and gyrA D95N/G, DNA topoisomerase IV subunit A ParC	Neisseria gonorrhoeae, Pseudomonas aeruginosa, Neisseria meningitidis	ciprofloxacin\|gatifloxacin\|levofloxacin\|ofloxacinfluoroquinolonesciprofloxacin\|levofloxacin+3 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC DNA topoisomerase IV subunit C	E91Q	-	High-level resistance when additional to gyrA S91P and gyrA D95N/G, DNA topoisomerase IV subunit A ParC	Neisseria gonorrhoeae	ciprofloxacinfluoroquinolonesquinolones	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC topoisomerase IV subunit C	E92K	-	-	Salmonella enterica	ciprofloxacinciprofloxacin\|nalidixic acid	Reslit	Candidate
parC topoisomerase IV subunit C	E93K	-	-	Aeromonas salmonicida	ciprofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit A	E95K	-	-	Mycoplasma hominis	levofloxacin\|moxifloxacin	Reslit	Candidate
parC topoisomerase IV ParC subunit	E95Q	-	-	-	ciprofloxacin\|ofloxacin\|sparfloxacin\|trovafloxacin	Reslit	Candidate