Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC DNA gyrase subunit A	G32S	-	-	Neisseria gonorrhoeae	ciprofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit C	G35A	-	-	Shigella flexneri	ciprofloxacin\|levofloxacin	Reslit	Candidate
parC topoisomerase IV	G35E	-	incurs a high fitness cost in the absence of CIP	Acinetobacter baumannii	ciprofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit C	G569S	-	-	Acinetobacter baumannii	fluoroquinolones	Reslit	Candidate
parC topoisomerase IV subunit	G71E	-	-	-	quinolones	Reslit	Candidate
parC topoisomerase IV subunit	G78C	-	Target modification, DNA topoisomerase IV subunit A ParC	Escherichia coli, Acinetobacter baumannii, Salmonella enterica, Mycoplasma genitalium	ciprofloxacinnorfloxacinfluoroquinolones+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC Topoisomerase IV subunit C	G78D	G234A	increased resistance to fluoroquinolones, Target modification, DNA topoisomerase IV subunit A ParC	Salmonella Typhimurium, Salmonella Enteritidis, Escherichia coli, Salmonella enterica	ciprofloxacinlevofloxacinfluoroquinolones+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC	G78K	-	DNA topoisomerase IV subunit A ParC	Escherichia coli	quinolones	Reference Gene Catalog	Established
parC DNA topoisomerase IV subunit C	G78S	-	-	Escherichia coli	ciprofloxacin\|norfloxacin\|ofloxacin	Reslit	Candidate
parC topoisomerase IV subunit C	G81C	G241T	single resistance variant	Mycoplasma genitalium, Mycoplasmoides genitalium	fluoroquinolonesmoxifloxacinmacrolides+1 more	Card DatabaseReslit	Confirmed