Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parE topoisomerase IV subunit B	D434N	-	single resistance variant	Staphylococcus epidermidis, Staphylococcus aureus	levofloxacin\|gatifloxacin\|moxifloxacin\|tosufloxacinfluoroquinolones	Card DatabaseReslit	Confirmed
parE topoisomerase IV subunit B	D435E	-	-	Streptococcus pneumoniae	ciprofloxacinlevofloxacin\|ciprofloxacin	Reslit	Candidate
parE DNA topoisomerase IV subunit	D435G	-	-	Streptococcus pneumoniae	levofloxacin\|sparfloxacin	Reslit	Candidate
parE DNA topoisomerase IV subunit	D435N	G1305A	-	Streptococcus pneumoniae, Streptococcus pseudopneumoniae, Streptococcus mitis, Streptococcus oralis	levofloxacin\|clinafloxacinciprofloxacin\|garenoxacin\|sparfloxacin\|trovafloxacinfluoroquinolones+6 more	Reslit	Supported
parE topoisomerase IV subunit B	D435V	-	-	Streptococcus pneumoniae	levofloxacin\|ofloxacin\|ciprofloxacin	Reslit	Candidate
parE topoisomerase IV subunit B	D437N	-	-	Neisseria gonorrhoeae	ciprofloxacin\|garenoxacin\|sitafloxacin	Reslit	Candidate
parE topoisomerase IV subunit E	D442N	-	-	Haemophilus haemolyticus	levofloxacin\|tosufloxacin\|moxifloxacin	Reslit	Candidate
parE	D443E	-	DNA topoisomerase IV subunit B ParE	Staphylococcus aureus	quinolones	Reference Gene Catalog	Established
parE topoisomerase IV subunit E	D462G	-	-	Pseudomonas aeruginosa	fluoroquinolones	Reslit	Candidate
parE DNA topoisomerase IV subunit B	D475E	-	DNA topoisomerase IV subunit B ParE	Escherichia coli, E. coli	norfloxacin\|ciprofloxacinciprofloxacinciprofloxacin\|nalidixic acid+1 more	Reference Gene CatalogReslit	Confirmed