Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ampD AmpD	R161H	-	The Arg161His substitution was predicted to weaken ligand binding, likely affecting the positioning of the ligand in the active site.	Klebsiella aerogenes	ertapenem\|imipenem\|meropenem	Reslit	Candidate
ampD	R167S	-	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	Burkholderia cenocepacia	cephalosporins	Reference Gene Catalog	Established
ampD regulatory protein involved in AmpC β-lactamase expression	R22H	G65A	-	-	cefotaxime\|ceftazidime\|cefepime	Reslit	Candidate
ampD peptidoglycan recycling enzyme	R345Q	-	-	Pseudomonas aeruginosa	cephalosporins\|penicillin	Reslit	Candidate
ampD	R79G	-	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	Burkholderia cenocepacia	cephalosporins	Reference Gene Catalog	Established
ampD regulatory protein involved in AmpC β-lactamase expression	R93P	G278C	-	-	cefotaxime\|ceftazidime\|cefepime	Reslit	Candidate
ampD	S114P	-	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	Pseudomonas aeruginosa	cephalosporins	Reference Gene Catalog	Established
ampD	S120L	-	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	Burkholderia cenocepacia	cephalosporins	Reference Gene Catalog	Established
ampD regulatory protein involved in AmpC β-lactamase expression	S37R	A109C	-	-	cefotaxime\|ceftazidime\|cefepime	Reslit	Candidate
ampD	S44G	-	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	Burkholderia cenocepacia	cephalosporins	Reference Gene Catalog	Established