Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ampD	S5F	-	-	-	imipenem\|meropenem	Reslit	Candidate
ampD	S81P	-	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	Burkholderia cenocepacia	cephalosporins	Reference Gene Catalog	Established
ampD AmpC cephalosporinase regulator	T139M	-	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	Pseudomonas aeruginosa	ticarcillin\|piperacillin\|cefepime\|ceftazidime\|aztreonamcephalosporins	Reference Gene CatalogReslit	Confirmed
ampD peptidoglycan hydrolase	V10G	-	-	-	ceftazidime\|cefepime\|piperacillin\|tazobactam	Reslit	Candidate
ampD	V39A	-	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	Burkholderia cenocepacia	cephalosporins	Reference Gene Catalog	Established
ampD AmpD	V84X	-	loss of function	Enterobacter cloacae	cefoxitin\|cefotaxime\|cefepime\|ertapenem\|imipenem\|meropenem	Reslit	Candidate
ampD regulatory protein involved in AmpC β-lactamase expression	W7*	G21A	-	-	cefotaxime\|ceftazidime\|cefepime	Reslit	Candidate
ampD regulatory protein involved in AmpC β-lactamase expression	W95*	G285A	-	-	cefotaxime\|ceftazidime\|cefepime	Reslit	Candidate
ampD AmpD	W95L	-	The Trp95Leu substitution was predicted to weaken ligand binding, likely affecting the positioning of the ligand in the active site.	Klebsiella aerogenes	ertapenem\|imipenem\|meropenem	Reslit	Candidate
ampD cellobiohydrolase	Y127H	T381C	-	Pseudomonas aeruginosa	ceftazidime avibactam\|imipenem relebactam	Reslit	Candidate