Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA penicillin-binding protein 2	E285D	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2 (PBP-2)	E377K	-	-	Neisseria gonorrhoeae	cephalosporins	Reslit	Candidate
penA Penicillin-Binding Protein 2	F504L	T1512C	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefiximecefiximepenicillin\|cephalosporins+5 more	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 2	G120K	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2 (PBP-2)	G375T	-	-	Neisseria gonorrhoeae	cephalosporins	Reslit	Candidate
penA Penicillin-Binding Protein 2	G482S	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefixime	Reslit	Candidate
penA penicillin-binding protein 2	G542S	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	ceftriaxoneceftriaxone\|cefiximeceftriaxone\|ceftizoxime+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA penicillin-binding protein 2	G543S	-	-	-	ceftriaxone\|cefixime	Reslit	Candidate
penA penicillin-binding protein 2	G545S	-	decreased susceptibility, reduced reactivity for β-lactams, decreased susceptibility to cefixime and ceftriaxone, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefiximecefixime\|ceftibuten\|cefepime\|ceftriaxonecefixime+6 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA Penicillin-binding protein 2	G546A	-	-	Neisseria gonorrhoeae	cefixime	Reslit	Candidate