Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA penicillin-binding protein 2 (PBP2)	G546S	-	-	Neisseria gonorrhoeae	ceftriaxone\|cefiximecefiximecephalosporins	ResFinder DatabaseReslit	Confirmed
penA penicillin-binding protein 2	H514A	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA Penicillin-Binding Protein 2	H541N	-	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	penicillincefiximecephalosporins+2 more	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 2	I312M	-	decreased susceptibility, reduced reactivity for β-lactams, decreased susceptibility to cefixime and ceftriaxone, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefiximecephalosporinscefixime+5 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA Penicillin-Binding Protein 2	I515V	-	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	penicillinbeta lactams	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 1	I517V	-	-	Neisseria gonorrhoeae	ceftriaxone\|cefixime	Reslit	Candidate
penA penicillin-binding protein 2	I556V	-	-	Neisseria gonorrhoeae	cefiximeceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2	I566V	-	penicillin-binding protein PBP2 PenA	Neisseria meningitidis	cefiximepenicillinbeta lactams	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 2	K288R	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2	K555Q	-	-	Neisseria gonorrhoeae	cefiximeceftriaxone	Reslit	Candidate