Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA penicillin-binding protein 2	P551L	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	cefiximepenicillin\|cephalosporinscephalosporins+4 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA Penicillin-Binding Protein 2	P551S	-	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefiximecefiximecephalosporins+4 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA penicillin-binding protein 2	P552V	-	-	Neisseria gonorrhoeae	cefiximeceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2	Q291R	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA β-lactamase	R164H	-	-	Burkholderia thailandensis	ceftazidime	Reslit	Candidate
penA β-lactamase	R164S	-	-	Burkholderia thailandensis	ceftazidime	Reslit	Candidate
penA Penicillin-binding protein 2	R356H	-	-	Neisseria gonorrhoeae	cefixime	Reslit	Candidate
penA β-lactamase	R7K	-	no effect on PenA activity	Burkholderia pseudomallei	ceftazidime\|amoxicillin clavulanic acid	Reslit	Candidate
penA penicillin-binding protein 2	S341P	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2	S363C	-	had only a minor effect on acylation (1.5-fold decrease)	Neisseria gonorrhoeae	penicillin	Reslit	Candidate