Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrA transmembrane protein	L116V	-	-	E. coli	colistin	Reslit	Candidate
pmrA Lipopolysaccharide (lipid A)	L157Q	-	two-component system response regulator PmrA	Pseudomonas aeruginosa	colistin	Reference Gene CatalogReslit	Confirmed
pmrA response regulator	L63H	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
pmrA response regulator	L71R	C212G	mutated form of pmrA confers resistance to aminoglycosides, activated	Pseudomonas aeruginosa	gentamicin\|amikacinpolymyxinstobramycin+1 more	Reslit	Supported
pmrA two-component response regulator	L72F	-	-	Pseudomonas aeruginosa	colistin	Reslit	Candidate
pmrA response regulator	M12I	-	The mutation in pmrA (M12I) leads to constitutive activation of the PmrAB two-component system, resulting in increased expression of the pmrCAB operon and resistance to polymyxin B., associated with HR to colistin, two-component system response regulator PmrA	Acinetobacter baumannii	polymyxin bcolistin	Reference Gene CatalogReslit	Confirmed
pmrA two-component system response regulator	M215I	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
pmrA two-component system sensor kinase	N128I	-	-	E. coli	colistin	Reslit	Candidate
pmrA two-component system response regulator	P102H	-	constitutive activation	Acinetobacter baumannii	colistinpolymyxin bpolymyxins	Reslit	Supported
pmrA response regulator	P102R	C306G	altered phosphorylation, mutated pmrA gene leads to increased colistin resistance	Acinetobacter baumannii	colistin	Reslit	Supported