Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrA response regulator	G54E	GGT->GAG	altered phosphorylation	Acinetobacter baumannii	colistin	Reslit	Supported
pmrA two-component system response regulator	G56E	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
pmrA response regulator	H499R	-	The mutation in pmrA (H499R) leads to constitutive activation of the PmrAB two-component system, resulting in increased expression of the pmrCAB operon and resistance to polymyxin B.	Acinetobacter baumannii	polymyxin b	Reslit	Candidate
pmrA transmembrane protein	I128N	-	-	E. coli	colistin	Reslit	Candidate
pmrA response regulator	I13M	C40G	slowed phosphorylation, mutated pmrA gene leads to increased colistin resistance	Acinetobacter baumannii	colistin	Reslit	Candidate
pmrA two-component system response regulator	I173N	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
pmrA two-component system response regulator	I178T	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
pmrA two-component system response regulator	I235T	-	-	Acinetobacter baumannii	colistin	Reslit	Candidate
pmrA transcriptional regulatory protein	K172I	-	-	Acinetobacter baumannii	colistin	Reslit	Candidate
pmrA two-component system sensor kinase	L105P	-	activates eptA and arnT	Escherichia coli, Klebsiella pneumoniae	colistin	Reslit	Candidate