Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrA response regulator	G157T	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
pmrA response regulator	G15R	-	affects protein function, Target modification, two-component system response regulator PmrA	Salmonella enterica, E. coli	polymyxin b\|colistincolistin	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
pmrA two-component response regulator	G35D	-	mutant PmrB results in coresistance to aminoglycosides and colistin	Pseudomonas aeruginosa	polymyxin b	Reslit	Candidate
pmrA response regulator	G423C	-	mutated form of pmrB confers resistance to aminoglycosides	Pseudomonas aeruginosa	gentamicin\|amikacin	Reslit	Candidate
pmrA response regulator	G53A	-	constitutive activation of PmrA or PmrB, subsequent overexpression of LPS modifying enzymes and thus colistin resistance	Enterobacterales, Escherichia coli, Salmonella spp.	colistin	Reslit	Candidate
pmrA regulator protein of the PmrA/PmrB two-component system	G53C	-	two-component system response regulator PmrA	Klebsiella pneumoniae	colistin	Reference Gene CatalogReslit	Confirmed
pmrA response regulator	G53E	-	mutant confers resistance to colistin, Target modification, two-component system response regulator PmrA	Salmonella enterica	polymyxin b\|colistincolistinpolymyxins	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
pmrA response regulator	G53R	-	affects protein function, predicted to affect the function of PmrB based on SIFT score (<0.05), Target modification, two-component system response regulator PmrA	Salmonella enterica, Klebsiella aerogenes, E. coli, Escherichia coli, Klebsiella pneumoniae	polymyxin b\|colistincolistinpolymyxin b	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
pmrA regulator protein of the PmrA/PmrB two-component system	G53S	-	two-component system response regulator PmrA	Klebsiella pneumoniae, Escherichia coli	colistinpolymyxins	Reference Gene CatalogReslit	Confirmed
pmrA	G53V	-	constitutive activation of the PmrA regulon, deleterious	Klebsiella pneumoniae, Escherichia coli	colistinpolymyxin b	Reslit	Supported