Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
pmrB transmembrane protein | T235N | - | - | Escherichia coli, Acinetobacter baumannii | colistin | Reslit | Candidate |
pmrB regulatory protein | T240M | - | - | - | colistin | Reslit | Candidate |
pmrB two-component system response regulator | T246A | - | enhanced ATP binding affinity and protein stability | Klebsiella pneumoniae | colistinpolymyxin bpolymyxins | Reslit | Supported |
pmrB sensor kinase | T253M | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | Reference Gene CatalogReslit | Confirmed |
pmrB two-component system histidine kinase | T269P | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
pmrB two-component system histidine kinase | T296S | - | altered | Klebsiella aerogenes | colistin | Reslit | Candidate |
| T343A | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Established | |
pmrB two-component sensor kinase | T4A | - | activating mutation | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
pmrB histidine kinase | T7I | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
pmrB regulator of lipid A modification | T89P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
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