Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrB histidine kinase	T156A	-	-	-	colistin	Reslit	Candidate
pmrB two-component system histidine kinase	T156K	-	-	E. coli	colistin	Reslit	Candidate
pmrB histidine kinase	T156M	-	Target modification, two-component system sensor histidine kinase PmrB	E. coli, Salmonella enterica, Escherichia coli	polymyxin b\|colistincolistin	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
pmrB histidine kinase	T156P	-	Target modification, two-component system sensor histidine kinase PmrB	Salmonella enterica	polymyxin b\|colistincolistin	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
pmrB	T157P	-	constitutive activation of PmrA, deleterious, mutant pmrB gene leads to activation of the pmrHFIJKLM operon, which modifies lipopolysaccharide (LPS) with 4-amino-4-deoxy-L-arabinose (L-Ara4N) or phosphoethanolamine (pEtN), deleterious to protein structure/function, two-component system sensor histidine kinase PmrB	Klebsiella pneumoniae	colistinpolymyxinscarbapenems+1 more	Reference Gene CatalogReslit	Confirmed
pmrB histidine kinase	T158I	-	-	Pseudomonas aeruginosa	colistin	Reslit	Candidate
pmrB regulatory protein involved in colistin resistance	T159M	C475T	-	E. coli	colistin	Reslit	Candidate
pmrB two-component system histidine kinase	T232A	-	-	Acinetobacter baumannii	colistin	Reslit	Candidate
pmrB two-component system sensor kinase	T232I	-	two-component system sensor histidine kinase PmrB	Acinetobacter baumannii	polymyxin bcolistin	Reference Gene CatalogReslit	Confirmed
pmrB histidine kinase	T235I	-	associated with stable resistance, two-component system sensor histidine kinase PmrB	Acinetobacter baumannii	polymyxin bcolistin	Reference Gene CatalogReslit	Confirmed