Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA pyrazinamidase	D49G	A148G A147G	disrupts metal ion binding and catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamidepza	Card DatabaseReslit	Confirmed
pncA	D49H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA pyrazinamidase	D49N	-	loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA	D49V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA	D49Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA pyrazinamidase	D53A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase	D53N	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
pncA pyrazinamidase	D63A	A188C GAT->GCA	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	Card DatabaseReslit	Confirmed
pncA	D63E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA pyrazinamidase	D63G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed