Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA Pyrazinamidase	G78D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase	G78R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
pncA pyrazinamidase	G78S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase	G78V	G233T	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase	G97C	G289T	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase	G97D	G289A	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA	G97R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA pyrazinamidase	G97S	-	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA	G97V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA pyrazinamidase	H137D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed