Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB β subunit of RNA polymerase	S488T	-	single resistance variant	Clostridium difficile, Clostridium ljungdahlii	rifampicin\|rifaximinrifampicin	Card DatabaseReslit	Confirmed
rpoB	S488Y	-	DNA-directed RNA polymerase subunit beta RpoB	Clostridioides difficile	rifaximin	Reference Gene Catalog	Established
rpoB RNA polymerase beta subunit	S490L	-	The S490L mutation in rpoB confers rifampicin resistance in B. velezensis.	Bacillus velezensis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S491F	-	upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic, mutated	Enterococcus faecium	daptomycindaptomycin\|rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S491L	-	-	Enterococcus faecium	rifampicin	Reslit	Candidate
rpoB DNA-directed RNA polymerase beta chain	S492F	-	-	Flavobacterium psychrophilum	rifampicin	Reslit	Candidate
rpoB RNA polymerase subunit	S492L	-	-	Escherichia coli	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S493L	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	S493R	TCA->CGA	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB	S498T	-	single resistance variant	Clostridium ljungdahlii	rifampicin	Card Database	Established