Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaSHV-1 beta-lactamase	G238Q	-	demonstrated lower levels of resistance	Escherichia coli	penicillin\|cephalosporins	Reslit	Candidate
blaSHV-1 beta-lactamase	G238S	-	conferred resistance to penicillins and cephalosporins	Escherichia coli	penicillin\|cephalosporinscefotaxime\|ceftazidime	Reslit	Candidate
blaSHV-1 β-lactamase	L138P	-	reduced role in penicillin and ampicillin hydrolyzing properties	Escherichia coli, Klebsiella pneumoniae	penicillin\|ampicillin	Reslit	Candidate
blaSHV-1 β-lactamase	R164A	-	-	Escherichia coli	ceftazidime	Reslit	Candidate
blaSHV	-	C-112A	blaSHV promoter region	Klebsiella pneumoniae	cefiderocol\|cephalosporins	Reference Gene Catalog	Established
blaSHV beta-lactamase	E240K	-	confers extended-spectrum beta-lactamase (ESBL) activity	Klebsiella pneumoniae, Escherichia coli	ceftazidime\|cefotaxime\|aztreonamcefoxitin\|cefotaxime\|ceftazidime\|ceftriaxone\|penicillin\|amoxicillin\|oxacillin	Reslit	Candidate
blaSHV β-lactamase	G238A	-	-	Escherichia coli, Klebsiella pneumoniae	cefoxitin\|cefotaxime\|ceftazidime\|ceftriaxone\|penicillin\|amoxicillin\|oxacillin	Reslit	Candidate
blaSHV beta-lactamase	G238S	-	confers extended-spectrum beta-lactamase (ESBL) activity	Klebsiella pneumoniae, Escherichia coli	ceftazidime\|cefotaxime\|aztreonamcefoxitin\|cefotaxime\|ceftazidime\|ceftriaxone\|penicillin\|amoxicillin\|oxacillin	Reslit	Candidate
blaSHV β-lactamase	I8F	-	-	Escherichia coli, Klebsiella pneumoniae	cefoxitin\|cefotaxime\|ceftazidime\|ceftriaxone\|penicillin\|amoxicillin\|oxacillin	Reslit	Candidate
blaSHV β-lactamase	L35Q	-	-	Escherichia coli, Klebsiella pneumoniae	cefoxitin\|cefotaxime\|ceftazidime\|ceftriaxone\|penicillin\|amoxicillin\|oxacillin	Reslit	Candidate