Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
acrB efflux pump	R717L	C2150T	reduces steric barriers associated with transit through the substrate channel 2 of AcrB, Target modification, multidrug efflux RND transporter permease subunit AcrB	Salmonella Typhi, Escherichia coli, Salmonella enterica, Salmonella typhimurium	azithromycinmacrolides\|fluoroquinolonesazithromycin\|clarithromycin\|erythromycin	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
acrB component of the AcrAB efflux pump	R717Q	G2152A	increases AZI efflux in the acrAB-TolC efflux pump, Target modification, multidrug efflux RND transporter permease subunit AcrB	Salmonella Typhi, Salmonella enterica, Escherichia coli, Salmonella Paratyphi	azithromycinmacrolidesmacrolides\|fluoroquinolones+1 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
acrB Multidrug efflux pump RND permease	S665A	-	-	E. coli	tetracycline	Reslit	Candidate
acrB multidrug efflux pump	S966A	-	-	Klebsiella pneumoniae	tetracycline\|cefoxitin	Reslit	Candidate
acrB multidrug efflux pump	T104A	-	-	Escherichia coli	phenicols\|erythromycin	Reslit	Candidate
acrB efflux transporter	T37W	-	-	Escherichia coli	erythromycin\|ethidium bromide	Reslit	Candidate
acrB efflux pump component	V1127G	-	-	Escherichia coli	phenicols\|ampicillin\|cefoxitin	Reslit	Candidate
acrB multidrug efflux pump protein	V127A	-	-	Escherichia coli	erythromycin\|novobiocin	Reslit	Candidate
acrB multidrug efflux pump protein	V127G	-	-	Escherichia coli	erythromycin\|novobiocin	Reslit	Candidate
acrB	V12I	-	-	-	imipenem	Reslit	Candidate