Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
acrB efflux pump component	L716R	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
acrB multidrug efflux transporter	N282Y	-	impairs the efflux inhibitory action of NMP in a predominantly substrate-specific manner	Escherichia coli	linezolid	Reslit	Candidate
acrB efflux transporter	N298W	-	-	Escherichia coli	erythromycin\|ethidium bromide	Reslit	Candidate
acrB efflux pump component	P152S	-	-	Escherichia coli	fluoroquinolones	Reslit	Candidate
acrB efflux pump component	P189L	-	-	Escherichia coli	phenicols	Reslit	Candidate
acrB efflux pump component	Q176K	C527A	increases binding energy for cefotaxime, improving recognition in the distal binding pocket, multidrug efflux RND transporter permease subunit AcrB	Salmonella typhimurium, Salmonella enterica	cefotaximecephalosporins	Reference Gene CatalogReslit	Confirmed
acrB	R620C	-	multidrug efflux RND transporter permease subunit AcrB	Escherichia coli	tigecycline	Reference Gene Catalog	Established
acrB AcrB, the substrate-binding domain of the AcrAB-TolC system	R620S	-	hypersusceptibility toward ampicillin and colistin	Salmonella typhimurium	phenicols\|ampicillin	Reslit	Candidate
acrB AcrB protein	R653H	-	-	Francisella novicida, Francisella tularensis	ciprofloxacin\|doxycycline\|phenicols	Reslit	Candidate
acrB efflux pump component	R716L	-	-	Klebsiella pneumoniae	ceftazidime avibactam	Reslit	Candidate