Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrB DNA gyrase subunit B	E464K	-	-	Francisella tularensis	fluoroquinolones	Reslit	Candidate
gyrB DNA gyrase subunit B	E465K	-	-	Francisella tularensis	fluoroquinolones	Reslit	Candidate
gyrB DNA gyrase subunit B	E466C	-	-	Escherichia coli, Mycobacterium smegmatis	fluoroquinolones	Reslit	Candidate
gyrB DNA gyrase subunit B	E466D	-	Target modification, single resistance variant, DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Salmonella enterica, Escherichia coli, Proteus mirabilis, E. coli, Klebsiella pneumoniae	ciprofloxacinlevofloxacinciprofloxacin\|levofloxacin\|moxifloxacin+3 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrB DNA gyrase subunit B	E466K	G1397A	single resistance variant, DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Clostridium difficile, Salmonella typhimurium, Francisella tularensis, Clostridium ljungdahlii, Clostridioides difficile	moxifloxacinciprofloxacinfluoroquinolones+1 more	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrB DNA gyrase subunit B	E466Q	G1397C	-	Salmonella enterica	nalidixic acid\|enrofloxacinfluoroquinolones	Reslit	Supported
gyrB DNA gyrase subunit B	E466V	-	single resistance variant, DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Salmonella enterica, Clostridium ljungdahlii, Clostridioides difficile	fluoroquinolonesciprofloxacinquinolones	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrB DNA gyrase subunit B	E468D	-	DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Pseudomonas aeruginosa, Klebsiella pneumoniae, Pseudomonas putida	levofloxacinciprofloxacinfluoroquinolones+3 more	Reference Gene CatalogReslit	Confirmed
gyrB	E468H	-	DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Pseudomonas aeruginosa	quinolones	Reference Gene Catalog	Established
gyrB DNA gyrase subunit B	E468Q	-	-	Salmonella enterica	ciprofloxacin	Reslit	Candidate