Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrB DNA gyrase subunit B	R447K	C1340T	single resistance variant, DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Clostridium difficile, Clostridioides difficile, Clostridium ljungdahlii	moxifloxacin\|ciprofloxacin\|levofloxacinmoxifloxacin\|levofloxacinlevofloxacin\|ciprofloxacin+2 more	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrB DNA gyrase subunit B	R447L	-	single resistance variant, DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Clostridium difficile, Clostridium ljungdahlii, Clostridioides difficile	ciprofloxacin\|moxifloxacinfluoroquinolonesquinolones	Card DatabaseReference Gene CatalogReslit	Confirmed
gyrB DNA gyrase subunit B	R450S	-	-	-	fluoroquinolones	Reslit	Candidate
gyrB	R457T	-	single resistance variant	Clostridium ljungdahlii	fluoroquinolones	Card Database	Established
gyrB DNA gyrase subunit B	R464K	-	-	Mycoplasma genitalium	moxifloxacin	Reslit	Candidate
gyrB DNA gyrase subunit B	R482K	-	The R482 side chain is located in the minor groove and forms a gate which blocks the quinolone in the pocket	Mycobacterium tuberculosis	fluoroquinolones	Reslit	Candidate
gyrB DNA gyrase subunit B	R484K	-	co-dependent single resistance variant	Helicobacter pylori	levofloxacinfluoroquinolones	Card DatabaseReslit	Confirmed
gyrB DNA gyrase subunit B	R484S	CGT>TCT	-	Helicobacter pylori	levofloxacin	Reslit	Candidate
gyrB DNA gyrase subunit B	R485C	-	confers resistance to ofloxacin, multiple resistance variants	Mycobacterium tuberculosis	ofloxacinfluoroquinolones	Card DatabaseReslit	Confirmed
gyrB DNA gyrase subunit B	R485H	-	-	Mycobacterium tuberculosis	ofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate