Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC Topoisomerase IV subunit C	S57T	-	Target modification, DNA topoisomerase IV subunit A ParC	Salmonella enterica, E. coli, Escherichia coli	ciprofloxacinnalidixic acid\|ciprofloxacinquinolones+3 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC DNA topoisomerase IV subunit C	S580N	-	-	Mycoplasma hyopneumoniae	enrofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit A	S58I	-	-	Escherichia coli	fluoroquinolonesciprofloxacin\|nalidixic acid	Reslit	Candidate
parC DNA topoisomerase	S60N	-	The mutation of S85I affects the binding conformation of ciprofloxacin.	Vibrio cholerae	ciprofloxacin	Reslit	Candidate
parC topoisomerase IV subunit C	S67C	-	-	Salmonella enterica	ciprofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit	S67F	-	-	Streptococcus suis	fluoroquinolones	Reslit	Candidate
parC topoisomerase IV subunit C	S739F	-	-	-	fluoroquinolones	Reslit	Candidate
parC topoisomerase IV subunit C	S79A	-	-	Streptococcus pneumoniae, Streptococcus pyogenes	levofloxacinciprofloxacinfluoroquinolones	Reslit	Supported
parC DNA topoisomerase IV subunit	S79F	C237T TCT->TTC G235T TCA->TTC AGC->TTC T236C	mutant ParC S79 residue is associated with drug resistance, DNA topoisomerase IV subunit A ParC	Streptococcus pneumoniae, Streptococcus pseudopneumoniae, Streptococcus mitis, Streptococcus oralis, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus dysgalactiae, Staphylococcus aureus, Streptococcus suis	levofloxacin\|clinafloxacinlevofloxacinciprofloxacin\|garenoxacin\|sparfloxacin\|trovafloxacin+19 more	Reference Gene CatalogReslit	Confirmed
parC DNA topoisomerase IV subunit A	S79I	-	-	Streptococcus pneumoniae	levofloxacin	Reslit	Candidate