Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC topoisomerase IV subunit	S79L	-	-	Streptococcus pneumoniae	ciprofloxacin\|levofloxacin\|moxifloxacin\|gatifloxacin\|gemifloxacin\|garenoxacin\|norfloxacin	Reslit	Candidate
parC topoisomerase IV subunit C	S79P	-	-	-	fluoroquinolones	Reslit	Candidate
parC topoisomerase IV subunit C	S79R	-	-	Streptococcus pneumoniae	fluoroquinolones	Reslit	Candidate
parC DNA topoisomerase IV subunit	S79Y	G235C AGC->TAT AGT->TAT T236A	DNA topoisomerase IV subunit A ParC	Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus oralis, Streptococcus mitis	clinafloxacin\|ciprofloxacin\|trovafloxacinlevofloxacin\|clinafloxacinlevofloxacin+16 more	Reference Gene CatalogReslit	Confirmed
parC DNA topoisomerase IV subunit C	S80A	-	-	Staphylococcus aureus	moxifloxacin	Reslit	Candidate
parC topoisomerase IV subunit C	S80E	-	-	Escherichia coli, Shigella spp.	ciprofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit C	S80F	T238C TCG->TTT T240C	increased MIC levels, disrupts the water–metal ion bridge, single resistance variant, DNA topoisomerase IV subunit A ParC	Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma hyorhinis, Staphylococcus agnetis, Staphylococcus chromogenes, Staphylococcus arlettae, Staphylococcus lentus, Staphylococcus simulans, Proteus mirabilis, Escherichia coli, Salmonella typhimurium, Enterococcus faecalis, Yersinia enterocolitica, Salmonella enterica, Bacillus subtilis, Acinetobacter pittii, Streptococcus agalactiae, Acinetobacter baumannii, Mycoplasma hyopneumoniae	ciprofloxacin\|levofloxacin\|gatifloxacinfluoroquinolonesciprofloxacin\|ofloxacin\|gatifloxacin\|moxifloxacin+15 more	Card DatabaseReference Gene CatalogReslit	Confirmed
parC topoisomerase IV subunit C	S80G	-	-	-	fluoroquinolones	Reslit	Candidate
parC topoisomerase IV subunit C	S80I	TCA -> ATA A238G TCA->ATA TCT->ATT AGT->ATC TCA -> ATT G240T TCG->ATA TCC->ATC AGT->ATA TCT -> ATT T239A T238A G239T G241T T240A TCG->ATC	modified topoisomerase, confers resistance, disrupts the water–metal ion bridge, associated with fluoroquinolone resistance, resistance, mutations in GyrA (S83Y, S83F, D87G, D87N, D87Y) and ParC (S80I), Target modification, single resistance variant, DNA topoisomerase IV subunit A ParC	Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Escherichia coli, Salmonella enterica, Aeromonas caviae, Enterococcus faecium, Salmonella, Neisseria gonorrhoeae, Shigella sonnei, E. coli, Shigella flexneri, Spot-billed duck, Mycoplasma hominis, Staphylococcus epidermidis, Klebsiella spp., Salmonella Typhi, Salmonella Kentucky, Salmonella typhi, Enterobacter xiangfangensis, Enterobacter hoffmannii, Aeromonas hydrophila, Aeromonas sobria, Acinetobacter baumannii, Streptococcus agalactiae, Salmonella Typhimurium, Shigella dysenteriae, S. Typhi, Pseudomonas aeruginosa, Shigella boydii, Serratia marcescens, Mycoplasma genitalium, Mycoplasma bovis, Salmonella Paratyphi, Staphylococcus aureus, Morganella morganii, Klebsiella oxytoca, Proteus mirabilis, Staphylococcus pseudintermedius, Escherichia albertii, Staphylococcus agnetis, Staphylococcus saprophyticus, Salmonella Infantis, Providencia stuartii, Aeromonas veronii, Aeromonas dhakensis, Aeromonas jandaei, Aeromonas trota, Aeromonas media, Kocuria polaris, Klebsiella michiganensis, Gallibacterium anatis, Citrobacter freundii, Pseudomonas spp., Mycoplasma salivarium, non-typhoidal Salmonella, Enterococcus faecalis, K. pneumoniae	ciprofloxacinnalidixic acidnorfloxacin\|ciprofloxacin+56 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
parC DNA topoisomerase IV subunit C	S80L	TCA -> CTG TCC->CTC TCA->CTA TCG->TTG A240G	disrupts the water–metal ion bridge, Target modification, single resistance variant, DNA topoisomerase IV subunit A ParC	Salmonella enterica, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, E. coli, Staphylococcus agnetis, Staphylococcus chromogenes, Staphylococcus arlettae, Staphylococcus lentus, Staphylococcus simulans, Neisseria gonorrhoeae, non-typhoidal Salmonella, Salmonella, Mycoplasma gallisepticum, Bacillus anthracis, Mycobacterium tuberculosis, Actinobacteria, Shigella sonnei, Staphylococcus saprophyticus, Streptococcus pneumoniae	ciprofloxacinfluoroquinolonesciprofloxacin\|levofloxacin+7 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed