Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC topoisomerase IV subunit C	S80N	-	-	Escherichia coli, Mycoplasma genitalium	ciprofloxacinfluoroquinolones	Reslit	Supported
parC topoisomerase IV subunit C	S80P	-	-	Streptococcus pneumoniae	levofloxacinfluoroquinolones	Reslit	Supported
parC topoisomerase IV subunit C	S80Q	-	-	Escherichia coli	ciprofloxacin\|norfloxacin	Reslit	Candidate
parC topoisomerase IV subunit C	S80R	TCG > AGG	Mutations in the QRDRs of both GyrA/ParC alter the three-dimensional structure of the target protein. Alteration of the target protein structure reduces the affinity of quinolones for the enzyme-DNA complex, efflux pump overexpression, resistance to ciprofloxacin, Target modification, DNA topoisomerase IV subunit A ParC	Klebsiella oxytoca, Salmonella enterica, Enterococcus faecium, Salmonella, Salmonella Typhimurium, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Acinetobacter baumannii, Salmonella typhi, Aeromonas caviae, Aeromonas hydrophila, Aeromonas sobria, Stenotrophomonas maltophilia, Yersinia enterocolitica, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Acinetobacter pittii, Citrobacter freundii, Enterobacter cloacae, Proteus mirabilis, Serratia marcescens, Pseudomonas aeruginosa, Salmonella Indiana, E. coli, Shigella flexneri	ciprofloxacinciprofloxacin\|nalidixic acidnalidixic acid\|ciprofloxacin+16 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC	S80T	-	-	Escherichia coli	ciprofloxacin\|levofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit C	S80V	-	-	Escherichia coli, Staphylococcus agnetis, Staphylococcus saprophyticus	ciprofloxacin\|norfloxacin\|ofloxacinciprofloxacin	Reslit	Candidate
parC Topoisomerase IV subunit C	S80W	-	Target modification, DNA topoisomerase IV subunit A ParC	Acinetobacter baumannii, Escherichia coli, Salmonella enterica	ciprofloxacin\|gemifloxacin\|levofloxacin\|norfloxacin\|gatifloxacinciprofloxacin\|nalidixic acidciprofloxacin+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parC topoisomerase IV subunit A	S80Y	TCG->TAT T240A	single resistance variant, DNA topoisomerase IV subunit A ParC	Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma hyorhinis, Staphylococcus agnetis, Staphylococcus chromogenes, Staphylococcus arlettae, Staphylococcus lentus, Staphylococcus simulans, Klebsiella pneumoniae, Streptococcus agalactiae, Pseudomonas aeruginosa, Shigella sonnei, Mycoplasma hyopneumoniae, Escherichia coli	fluoroquinolonesciprofloxacin\|levofloxacinciprofloxacin\|ofloxacin\|gatifloxacin\|moxifloxacin+9 more	Card DatabaseReference Gene CatalogReslit	Confirmed
parC DNA gyrase subunit A	S81F	C244T	-	Streptococcus pneumoniae, Bacillus anthracis	levofloxacin\|ciprofloxacinfluoroquinolonesciprofloxacin\|levofloxacin+2 more	Reslit	Supported
parC topoisomerase IV subunit C	S81I	-	-	Erysipelothrix rhusiopathiae, E. coli	fluoroquinolonesenrofloxacinenrofloxacin\|ciprofloxacin	Reslit	Supported