Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC DNA gyrase subunit B	S83I	G248T	single resistance variant	Mycoplasma genitalium, Vibrio cholerae, Escherichia coli, Mycoplasmoides genitalium	fluoroquinolonesmoxifloxacinciprofloxacin\|nalidixic acid+5 more	Card DatabaseReslit	Confirmed
parC topoisomerase IV subunit C	S83L	AGT -> TTG C248T	mutation in parC gene results in substitution of serine by leucine at position 83 (S83L), single resistance variant	Mycoplasma hominis, Ureaplasma spp., Ureaplasma urealyticum, Ureaplasma parvum, Shigella dysenteriae, Escherichia coli, Mycoplasma genitalium	fluoroquinolonesmoxifloxacinlevofloxacin+3 more	Card DatabaseReslit	Confirmed
parC DNA gyrase subunit B	S83N	G248A	single resistance variant	Mycoplasma genitalium, Mycoplasmoides genitalium	fluoroquinolonesmoxifloxacin	Card DatabaseReslit	Confirmed
parC DNA gyrase subunit B	S83R	T249A	single resistance variant	Mycoplasma genitalium, Mycoplasmoides genitalium	fluoroquinolonesmoxifloxacin	Card DatabaseReslit	Confirmed
parC DNA gyrase subunit B	S83V	-	-	Mycoplasma genitalium	fluoroquinolones	Reslit	Candidate
parC DNA gyrase subunit A	S83W	C248G	single resistance variant	Ureaplasma sp., Ureaplasma spp., Mycoplasma hominis, Ureaplasma parvum	levofloxacinlevofloxacin\|moxifloxacinfluoroquinolones	Card DatabaseReslit	Confirmed
parC DNA topoisomerase IV subunit A	S84F	-	single resistance variant, DNA topoisomerase IV subunit A ParC	Haemophilus parainfluenzae, Acinetobacter baumannii	quinolonesciprofloxacinfluoroquinolones	Card DatabaseReference Gene CatalogReslit	Confirmed
parC DNA gyrase subunit B	S84G	-	-	Mycoplasma genitalium	fluoroquinolones	Reslit	Candidate
parC DNA gyrase subunit B	S84H	-	-	Mycoplasma genitalium	fluoroquinolones	Reslit	Candidate
parC DNA gyrase subunit B	S84I	-	DNA topoisomerase IV subunit A ParC	Mycoplasma genitalium, Proteus mirabilis, Haemophilus quentini, Haemophilus influenzae, non-typeable Haemophilus	fluoroquinolonesciprofloxacinlevofloxacin\|nalidixic acid+3 more	Reference Gene CatalogReslit	Confirmed