Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC topoisomerase IV	S84L	AGT->CTT	antibiotic target alteration, single resistance variant, DNA topoisomerase IV subunit A ParC	Acinetobacter baumannii, Pasteurella multocida, Yersinia enterocolitica, Salmonella enterica, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Acinetobacter pittii, Acinetobacter nosocomialis, Pseudomonas aeruginosa, Non-baumannii Acinetobacter	fluoroquinolonesciprofloxacinenrofloxacin\|danofloxacin+4 more	Card DatabaseReference Gene CatalogReslit	Confirmed
parC DNA gyrase subunit B	S84P	-	single resistance variant	Mycoplasma genitalium, Ureaplasma parvum, Ureaplasma urealyticum	fluoroquinolonesciprofloxacin\|levofloxacin\|sitafloxacin\|tosufloxacin\|garenoxacin	Card DatabaseReslit	Confirmed
parC DNA gyrase subunit B	S84R	-	DNA topoisomerase IV subunit A ParC	Mycoplasma genitalium, Haemophilus influenzae	fluoroquinoloneslevofloxacin\|tosufloxacin\|moxifloxacinquinolones	Reference Gene CatalogReslit	Confirmed
parC	S84W	-	DNA topoisomerase IV subunit A ParC	Acinetobacter baumannii	quinolones	Reference Gene Catalog	Established
parC topoisomerase IV subunit A	S84Y	-	-	Staphylococcus epidermidis	levofloxacin\|gatifloxacin\|moxifloxacin\|tosufloxacin	Reslit	Candidate
parC topoisomerase IV ParC subunit	S85F	-	DNA topoisomerase IV subunit A ParC	Vibrio parahaemolyticus, Vibrio cholerae, Escherichia coli	ciprofloxacinciprofloxacin\|nalidixic acidquinolones	Reference Gene CatalogReslit	Confirmed
parC DNA topoisomerase	S85I	-	The mutation of S85I affects the binding conformation of ciprofloxacin., DNA topoisomerase IV subunit A ParC	Vibrio cholerae, Enterococcus faecalis	ciprofloxacinlevofloxacinfluoroquinolones+1 more	Reference Gene CatalogReslit	Confirmed
parC Topoisomerase IV subunit C	S85L	-	DNA topoisomerase IV subunit A ParC	Vibrio cholerae, Vibrio vulnificus, Vibrio parahaemolyticus	norfloxacin\|ciprofloxacin\|sparfloxacin\|ofloxacinfluoroquinolonesciprofloxacin+6 more	Reference Gene CatalogReslit	Confirmed
parC topoisomerase IV subunit C	S86R	-	-	-	ciprofloxacin	Reslit	Candidate
parC DNA topoisomerase IV subunit C	S87C	-	DNA topoisomerase IV subunit A ParC	Neisseria gonorrhoeae	ciprofloxacinciprofloxacin\|garenoxacin\|sitafloxacinquinolones	Reference Gene CatalogReslit	Confirmed