Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parE DNA topoisomerase IV subunit	I476F	-	-	Streptococcus pneumoniae	fluoroquinolones	Reslit	Candidate
parE DNA topoisomerase IV ParE subunit	I493L	A1480C	-	Streptococcus pneumoniae	ciprofloxacin\|levofloxacin\|sparfloxacin\|trovafloxacinfluoroquinolones	Reslit	Candidate
parE DNA topoisomerase IV subunit B	I529L	A1586C	Target modification, DNA topoisomerase IV subunit B ParE	Escherichia coli, Klebsiella pneumoniae, Klebsiella spp., E. coli	norfloxacin\|ciprofloxacinquinolonesciprofloxacin+7 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE DNA topoisomerase IV subunit B	I575T	-	-	-	fluoroquinolones	Reslit	Candidate
parE DNA topoisomerase IV subunit B	K568N	-	-	-	fluoroquinolones	Reslit	Candidate
parE DNA topoisomerase IV subunit A	L416F	G1249T T1247C	Target modification, DNA topoisomerase IV subunit B ParE	Escherichia coli, Salmonella enterica, E. coli, Salmonella Typhi	ciprofloxacinciprofloxacin\|levofloxacinciprofloxacin\|levofloxacin\|norfloxacin+6 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE DNA topoisomerase IV subunit A	L445H	-	Target modification, DNA topoisomerase IV subunit B ParE	Escherichia coli	ciprofloxacinciprofloxacin\|nalidixic acidnalidixic acid\|ciprofloxacin+1 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE topoisomerase IV ParE subunit	L446F	-	-	Mycoplasma hominis	ofloxacin\|pefloxacin	Reslit	Candidate
parE topoisomerase IV subunit B	L477M	CTT->ATG	-	Escherichia coli	ciprofloxacin	Reslit	Candidate
parE topoisomerase IV subunit E	L502F	-	DNA topoisomerase IV subunit B ParE	Haemophilus haemolyticus, Haemophilus influenzae	levofloxacin\|tosufloxacin\|moxifloxacinquinolones	Reference Gene CatalogReslit	Confirmed